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Dr. Barry Sears
Dr. Barry Sears
President of Zone Labs
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Please visit the Zone Living Web Site for books like The Anti-Inflammation Zone, The Omega-Rx Zone, Zone Perfect Meals in Minutes, and more!

Why it Hurts: Pain and Inflammation

Dr. Barry Sears
Zone Living Pain is often the hallmark of disease. Chronic pain itself is not a defined medical condition, but rather a symptom in the body that something has gone awry. Pain usually stems from inflammation of the body’s tissues. Although there is no blood test for pain, the patient is acutely aware of its existence.

Throughout the centuries, one of the most pressing goals for medical researchers has been to find more effective ways to diminish pain. As medicine enters the 21st century, we are still seeking a perfect pain reliever with no side effects. After all, end-stage cancer patients are still given morphine, a narcotic drug that was used during the Civil War, to dull their excruciating pain. And experts on pain are sizing up the benefits of marijuana for their patients. Somehow we haven’t been able to develop a pain reliever that’s truly effective and doesn’t cause a drug-induced high.

Sometimes physicians can’t make a definitive medical diagnosis to explain the underlying cause of chronic pain. They may shrug their shoulders or use a term like fibromyalgia, a diagnosis made to describe intense, diffuse pain of unknown origin. Regardless of whether a definitive cause of chronic pain can be found, every patient knows that the pain is very, very real.

The most powerful pain relievers, however, are corticosteroids. They have an immediate effect, but they knock out all eicosanoids – “good” and “bad” – indiscriminately. This can lead to severe side effects, such as immune depression, cognitive impairment, and diabetes.

Aspirin, on the other hand, affects a more limited number of eicosanoids (only prostaglandins and thromboxanes), but at least it knocks out the “bad” eicosanoids at a slightly faster rate than it knocks out the “good” ones. Nonsteroidal anti-inflammatory drugs (such as Advil) also work like aspirin. In recent years, new and very expensive medications called COX-2 inhibitors were added to the stockpile of pain relievers. These have a little more selectivity than aspirin, but not as corticosteroids.

Corticosteroids, aspirin, and other anti-inflammatory drugs inhibit the actions of enzymes that make “bad” eicosanoids, whereas Ultra Refined high-dose fish oil reduces the actual building block (arachidonic acid)) necessary to make the same “bad” eicosanoids. The medications won’t reduce the building blocks of “bad” eicosanoids, so it’s almost as if you’re fighting an uphill battle against pain. Ultra Refined high-dose fish oil, on the other hand, reduces the materials necessary to make these weapons of pain.* Thus, you’re able to charge downhill to conquer your enemy. This explains why Ultra Refined high-dose fish oil can so effectively keep inflammatory pain under control.

While medicine has a variety of blood tests to check for heart disease and diabetes, it has virtually none to test for pain. The primary way your doctor determines the extent of your pain is by your own reporting of symptoms. Medical science has coined a lot of terms to describe the various parts of your body that hurt. Many end in –itis, a Greek root meaning inflammation. Below are some common forms of inflammatory pain.

Inflammatory Pain

Name Body Part That Hurts
Arthritis Joints
Encephalitis Brain
Pancreatitis Pancreas
Hepatitis Liver
Meningitis Brain
Bronchitis Lungs
Colitis Colon
Gastritis Stomach
Tendonitis Muscle Tendon


I think you get the picture. Virtually wherever your pain is, it comes from the overproduction of “bad” eicosanoids like prostaglandins or leukotrienes. Always striving for balance, your body also produces an equally impressive number of “good” eicosanoids that decrease pain. The trick is to achieve the right level of the “good” and the “bad.” As you now know, our lifestyles favor an overproduction of “bad” eicosanoids. That’s why you need to reach the Anti Inflammation Zone: to shift the scales the other way in order to strike an appropriate balance of eicosanoids. This process will limit the amount of insulin in your blood while providing sufficient levels of Ultra Refined high-dose fish oil.

Controlling this super hormone known as eicosanoids has 90 percent of the impact on the pain you feel – compared with a 10 percent impact by insulin (and thereby diet). This means that you need to focus most of your efforts on consuming Ultra Refined high-dose fish oil if your aim is to decrease chronic pain.

Besides fibromyalgia, a wide number of painful conditions caused by chronic inflammation can be alleviated once you are in the Anti Inflammation Zone.

Pain is an unfortunate hallmark of nearly every chronic disease. But the fact is that we can control pain much more than we think. All we have to do is get our “bad” eicosanoids under control. We can do this by using powerful drugs like corticosteroids, which have some serious side effects, or by choosing my dietary recommendations as the “drug” of choice. I know what I would choose: the option that hurts least.

I’m confident that Ultra Refined high-dose fish oil, especially when coupled with improved insulin control, will have a significant role to play in the treatment of chronic pain, including arthritis.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. As with any natural product, individual results will vary.

For more information about Dr. Barry Sears, his incredible fish oil supplements, or the popular Zone Diet, please visit

If you purchase any Zone Labs, Inc. products, part of the proceeds support CBN ministries.

Dr. Barry Sears is a leader in the field of dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his efforts over the past 25 years to the study of lipids and their inflammatory role in the development of chronic disease. He holds 13 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease.

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